⚡ Quick Revision: Excretion Fundamentals
🔹 The Need for Excretion
- ✔ Definition: Removal of chemical wastes (mainly nitrogenous) from the body.
- ✔ Major Waste: Urea, produced in the Liver from excess amino acids.
- ✔ Osmoregulation: Regulation of water and salt content (osmotic pressure) in the blood.
🔹 Primary Excretory Organs
| Organ | Main Excretory Product |
|---|---|
| Kidneys | Urea, excess water, salts (as Urine) |
| Sweat Glands | Water, salts, traces of urea |
| Lungs | Carbon dioxide ($CO_2$) and water vapor |
Homeostasis: Maintaining a constant internal environment of the body despite external changes.
Excretion with Egestion. Remember: Excretion is the removal of metabolic wastes (urea), while Egestion is the removal of undigested food (feces).
⚡ Quick Revision: Urinary System Anatomy
🔹 Gross Structure
- ✔ Kidneys: Bean-shaped organs; the left kidney is placed slightly higher than the right.
- ✔ Ureters: Two tubes that carry urine from the kidneys to the urinary bladder.
- ✔ Urinary Bladder: Muscular sac that stores urine temporarily; controlled by sphincter muscles.
🔹 Internal Structure of Kidney
- ✔ Cortex: The outer dark-colored zone of the kidney.
- ✔ Medulla: The inner lighter zone containing Renal Pyramids.
- ✔ Pelvis: The funnel-shaped space where urine collects before entering the ureter.
Nephron: The structural and functional unit of the kidney, also known as the uriniferous tubule.
Ureter with Urethra. Remember: Ureter carries urine from Kidney to Bladder; Urethra carries urine from Bladder to the Outside.
⚡ Quick Revision: Structure of a Nephron
🔹 Malpighian Corpuscle
- ✔ Bowman's Capsule: A hollow, cup-shaped structure that houses the glomerulus.
- ✔ Glomerulus: A knot of capillaries formed by the Afferent arteriole (wide) and leaving via the Efferent arteriole (narrow).
🔹 The Renal Tubule
- ✔ PCT & DCT: Proximal and Distal Convoluted Tubules located in the Cortex.
- ✔ Loop of Henle: U-shaped hair-pin loop that runs deep into the Medulla.
- ✔ Collecting Duct: Receives urine from multiple nephrons and opens into the pelvis.
Vasa Recta: The network of fine blood capillaries that surrounds the Loop of Henle.
Afferent with Efferent. Remember: Afferent Arrives (takes blood in); Efferent Exits (takes blood out).
⚡ Quick Revision: Mechanism of Urine Formation
🔹 Step 1: Ultrafiltration
- ✔ High Pressure: Narrow efferent arteriole creates hydrostatic pressure, forcing liquid out of the glomerulus.
- ✔ Glomerular Filtrate: Contains water, urea, glucose, and salts (No blood cells or large proteins).
🔹 Step 2: Selective Reabsorption
- ✔ PCT: All glucose, most water, and useful salts are reabsorbed back into the blood.
- ✔ Loop of Henle: Major site for water reabsorption to concentrate the urine.
🔹 Step 3: Tubular Secretion
- ✔ DCT: Active removal of $K^+$, $H^+$, and drugs from blood into the tubule.
- ✔ Final Product: Urine (consists of 95% water and 5% solid wastes like urea).
ADH (Vasopressin): Hormone that increases water reabsorption in the DCT and collecting duct, making urine concentrated.
Diabetes Mellitus with Diabetes Insipidus. Mellitus involves glucose in urine; Insipidus involves tasteless, dilute urine due to ADH deficiency.
⚡ Quick Revision: Properties of Urine & Osmoregulation
🔹 Physical Properties of Urine
- ✔ Color: Straw-yellow due to the pigment Urochrome (derived from breakdown of hemoglobin).
- ✔ pH: Slightly acidic (average pH 6.0), though it varies with diet.
- ✔ Volume: 1 to 1.5 liters per day, heavily influenced by fluid intake and physical activity.
🔹 Osmoregulation: Balancing Water
- ✔ Excessive Hydration: Pituitary secretes less ADH → PCT/DCT reabsorb less water → Dilute urine (Diuresis).
- ✔ Dehydration/Sweating: More ADH secreted → Increased water reabsorption → Concentrated urine.
Micturition: The process of expelling urine from the urinary bladder through the urethra.
Cholera with normal excretion. In Cholera, the kidneys may stop working because the blood becomes too thick (high viscosity) due to extreme dehydration.
⚡ Quick Revision: Dialysis & Disorders
🔹 Dialysis (Artificial Kidney)
- ✔ Mechanism: Blood is led from a main artery into a machine where urea and excess salts are filtered out across a cellophane membrane.
- ✔ Dialysing Fluid: Has the same composition as plasma but lacks nitrogenous wastes, allowing waste to diffuse out of the blood.
- ✔ Return: The "cleaned" blood is pumped back into the body through a vein.
🔹 Common Urinary Disorders
| Disorder | Characterized by... |
|---|---|
| Glycosuria | Presence of glucose in urine (Sign of Diabetes Mellitus). |
| Albuminuria | Presence of albumin (protein) in urine; indicates kidney damage. |
| Haematuria | Presence of blood in urine due to infection or stones. |
| Renal Calculi | Kidney stones formed by uric acid or calcium oxalate crystals. |
Uremia: A dangerous condition where urea accumulates in the blood because the kidneys fail to excrete it.
Always mention that the Efferent arteriole is narrower than the Afferent arteriole when explaining the cause of high hydrostatic pressure in the glomerulus.